API, Dawb los yog yuav luag dawb hmoov.
Cov mis mos molecular: C16H15F6N5O · H3PO4 · H2O
Cov khoom no yog siv nrog kev tswj hwm kev noj zaub mov thiab kev tawm dag zog los txhim kho cov ntshav qab zib hauv cov neeg mob ntshav qab zib hom 2. Thaum tswj ntshav qabzib tsis zoo nrog metformin hydrochloride ib leeg, nws tuaj yeem siv ua ke nrog metformin hydrochloride txhawm rau txhim kho cov ntshav qabzib hauv cov neeg mob ntshav qab zib hom 2 ntawm kev noj zaub mov thiab tawm dag zog.
Sigliptin dipeptidyl peptidase 4 (DPP-4) inhibitor tuaj yeem txhim kho kev tswj ntshav qabzib los ntawm kev nce qib ntawm cov nquag incretin hauv cov neeg mob ntshav qab zib hom 2. Cov tshuaj insulinotropic hauv plab, suav nrog glucagon zoo li peptide-1 (GLP-1) thiab qabzib nyob ntawm insulinotropic polypeptide (GIP), raug tso tawm los ntawm cov hnyuv thoob plaws hnub thiab nce qib tom qab noj mov. Txoj hnyuv islet stimulating hormone yog ib feem ntawm endogenous system koom nrog hauv kev tswj lub cev ntawm cov piam thaj homeostasis. Thaum cov ntshav qabzib hauv cov ntshav zoo li qub lossis nce siab, GLP-1 thiab GIP tuaj yeem ua rau pancreatic beta cell synthesis thiab tso cov tshuaj insulin los ntawm txoj hauv kev hauv lub cev uas qhia txog kev cuam tshuam nrog cyclic adenosine monophosphate. Hauv tus qauv tsiaj ntawm hom 2 mob ntshav qab zib mellitus, GLP-1 lossis DPP-4 inhibitor kev kho tuaj yeem txhim kho cov kev ua haujlwm ntawm cov txiav ua rau cov piam thaj thiab txhawb cov biosynthesis thiab tso tawm ntawm insulin. Thaum cov tshuaj insulin nce ntxiv, cov ntaub so ntswg ntawm cov piam thaj nce ntxiv. Tsis tas li ntawd, GLP-1 kuj tuaj yeem cuam tshuam qhov tso tawm ntawm glucagon los ntawm pancreatic alpha hlwb. Kev txo qis hauv glucagon concentration thiab nce qib ntawm cov tshuaj insulin tuaj yeem txo cov piam thaj hauv siab, yog li txo cov ntshav qabzib. Cov teebmeem ntawm GLP-1 thiab GIP yog nyob ntawm cov piam thaj. Thaum cov piam thaj hauv cov ntshav qis qis, GLP-1 tsis txhawb kev tso tawm insulin lossis inhibit glucagon secretion. Thaum cov piam thaj ntau dua li ib txwm muaj, GLP-1 thiab GIP txhim kho lawv lub peev xwm los txhawb kev tso tawm insulin. Tsis tas li ntawd, GLP-1 tsis ua rau lub cev glucagon tso tawm cov lus teb rau hypoglycemia. Kev ua haujlwm ntawm GLP-1 thiab GIP yog txwv los ntawm DPP-4 enzyme, uas tuaj yeem ua rau lub plab zom mov sai sai ntawm cov tshuaj insulinotropic los tsim cov khoom tsis ua haujlwm. Sitagliptin tuaj yeem tiv thaiv DPP-4 los ntawm hydrolyzing plab hnyuv insulinotropic cov tshuaj hormones, yog li ua kom cov ntshav concentration ntawm cov ntaub ntawv nquag ntawm GLP-1 thiab GIP. Los ntawm kev nce qib ntawm cov plab hnyuv siab rau insulinotropic hormone, sitagliptin tuaj yeem ua rau cov tshuaj insulin tso tawm thiab txo qis glucagon hauv cov piam thaj hauv cov ntshav. Rau cov neeg mob ntshav qab zib hom 2 uas muaj hyperglycemia, cov kev hloov pauv saum toj no hauv cov tshuaj insulin thiab glucagon tuaj yeem txo glycosylated hemoglobin A1c (HbA1c) thiab txo qis kev yoo mov thiab cov ntshav qabzib tom qab. Cov txheej txheem ntawm kev ua haujlwm ntawm Sigliptin yog qhov sib txawv ntawm cov tshuaj sulfonylurea. Txawm tias muaj cov piam thaj tsawg, cov tshuaj sulfonylurea tuaj yeem ua rau cov tshuaj insulin ntau ntxiv, yog li ua rau cov neeg mob ntshav qab zib hom 2 thiab cov neeg mob ib txwm muaj. Sitagliptin yog ib qho zoo thiab xaiv DPP-4 enzyme inhibitor uas tsis inhibit DPP-8 lossis DPP-9, uas muaj feem xyuam nrog DPP-4, ntawm kev kho mob ntau.
Cov tib neeg tsis haum rau tej yam khoom muaj nyob rau hauv cov khoom no yog txwv tsis pub siv nws.
Cim npe nrov: Tuam Tshoj Sitagliptin Phosphate Cisen Manufacturers thiab lwm tus neeg
