Cov khoom xyaw
Cov khoom tseem ceeb ntawm cov khoom no yog oxaliplatin. Nws lub npe tshuaj yog: (1R trans) - (1, 2-cyclohexanediamine-N, N ') [oxalic acid (2-) - O, O'] platinum, nrog lactose ua tus excipient
Cim
Cov khoom no yog dawb los yog tawm dawb xoob thaiv los yog amorphous khoom lossis hmoov.
Indications/Functional Indications
Oxaliplatin rau kev txhaj tshuaj yog qhia rau cov neeg mob uas mob qog nqaij hlav hauv plab hnyuv loj uas tsis tau kho nrog fluorouracil. Nws tuaj yeem siv ib leeg lossis ua ke nrog fluorouracil.
Cov khoom no belongs rau ib tug tshiab platinum derivative, nyob rau hauv lub central platinum atom yog surrounded los ntawm oxalic acid thiab 1, 2-diaminocyclohexane, tsim ib tug trans conformation thiab stereoisomer. Zoo li lwm yam platinum derivatives, oxaliplatin ua rau DNA los ntawm kev tsim cov alkylated complexes, tsim intra - thiab inter saw crosslinks, yog li inhibiting DNA synthesis thiab replication. Oxaliplatin khi nrawm rau DNA, siv sijhawm li 15 feeb, thaum cisplatin khi rau DNA hauv ob theem, suav nrog lub sijhawm ncua tom qab 48 teev. Tom qab ib teev ntawm kev tswj hwm hauv tib neeg lub cev, lub xub ntiag ntawm adducts tuaj yeem kuaj pom los ntawm kev ntsuas lawv qib hauv cov qe ntshav dawb. Lub DNA synthesis thaum lub sij hawm replication yog inhibited, tom qab ntawd los ntawm kev sib cais ntawm NDA thiab synthesis ntawm RNA thiab cellular proteins. Qee cov kab ntawm tes tiv taus cisplatin tau kho zoo nrog oxaliplatin.
Specifications
50mg ib.
Kev siv thiab ntau npaum li cas
Thov siv raws li kev qhia ntawm tus kws kho mob.
Nco ntsoov
1.Oxaliplatin yuav tsum tau siv nyob rau hauv kev saib xyuas ntawm ib tus kws kho mob uas muaj kev paub txog kev kho mob qog noj ntshav. Tshwj xeeb tshaj yog thaum ua ke nrog cov tshuaj uas muaj peev xwm neurotoxicity, neurological kev nyab xeeb ntawm oxaliplatin yuav tsum tau saib xyuas zoo.
2. Kev tiv thaiv lossis kho cov tshuaj antiemetic yuav tsum tau muab tshuaj.
Thaum cov ntshav toxicity tshwm sim (cov qe ntshav dawb<2000/mm3los yog platelets<50000/mm3), lub voj voog tom ntej ntawm cov tshuaj yuav tsum tau ncua kom txog thaum rov zoo.
4. Kev suav ntshav thiab kev faib cov ntshav yuav tsum tau ua ua ntej txhua yam kev kho mob, kev kuaj mob paj hlwb yuav tsum tau ua ua ntej pib ntawm txhua qhov kev kho mob, thiab tom qab ntawd yuav tsum tau ua raws li kev soj ntsuam tas li.
5. Yog hais tias tus neeg mob tseem muaj kev hnov mob txawv txav lossis / thiab kev ua haujlwm tsis zoo ntawm ob txoj kev kho mob, qhov ntau npaum li cas ntawm cov khoom no yuav tsum raug txo los ntawm 25%. Yog tias cov tsos mob tshwm sim los yog mob zuj zus tom qab kho cov tshuaj, cov tshuaj yuav tsum tau txiav.
6. Tsis txhob siv nrog cov tshuaj alkaline lossis cov xov xwm, cov tshuaj chloride, kev npaj alkaline, thiab lwm yam., thiab tsis txhob siv cov tshuaj txhaj tshuaj uas muaj txhuas.
Cia
Muab kaw thiab khaws cia hauv qab 25 degrees Celsius.
Cim npe nrov: Tuam Tshoj oxaliplatin rau txhaj tshuaj tiv thaiv qog, Tuam Tshoj oxaliplatin rau txhaj tshuaj tiv thaiv qog noj ntshav manufacturers, lwm tus neeg
