Dexmedetomidine hydrochloride yog cov organic compound nrog cov mis mos molecular C13H17ClN2. Nws yog ib qho alpha 2 adrenergic receptor agonist nrog analgesic thiab sedative kev ua.
Dexmedetomidine yog ib qho kev xaiv a2 adrenergic receptor agonist nrog cov teebmeem sedative. Thaum cov tsiaj tau txais kev txhaj tshuaj qeeb ntawm dexmedetomidine 10-300 μ g / kg, xaiv cov teebmeem ntawm a2 adrenergic receptors tuaj yeem pom. Txawm li cas los xij, ntawm cov koob tshuaj ntau dua (³ 1000mg / kg), qeeb lossis nrawm nrawm ntawm cov hlab ntsha tuaj yeem cuam tshuam rau ob qho tib si a1 thiab a2 receptors.
Genetic toxicity
Kev kuaj Ames thiab mammalian cell zoo noob hloov cov txiaj ntsig tau ob qho tib si tsis zoo rau dexmedetomidine. Kev kuaj hauv vitro human lymphocyte chromosome aberration test nyob rau hauv S9 metabolic activation tej yam kev mob nyob rau hauv nas thiab hauv vivo micronucleus kuaj nyob rau hauv NMRI nas tau zoo, tab sis nyob rau hauv vitro human lymphocyte chromosome aberration test nrog los yog tsis muaj S9 metabolic activation tej yam kev mob thiab hauv vivo micronucleus kuaj hauv CD1 nas tsis zoo.
Kev tsim tawm toxicity
Kev txhaj tshuaj subcutaneous txhua hnub ntawm dexmedetomidine ntawm qhov koob tshuaj txog li 54 μ g / kg (xws li mg / m2, qis dua qhov siab tshaj plaws tau pom zoo rau tib neeg cov tshuaj txhaj) tsis muaj kev cuam tshuam rau kev xeeb tub hauv txiv neej lossis poj niam nas 10 lub lis piam thiab 3 lub lis piam. ua ntej tus kheej mating mus txog rau mating.
Kev txhaj tshuaj subcutaneous ntawm dexmedetomidine ntawm koob tshuaj txog li 200 μ g / kg tau muab rau cov nas nyob rau hnub 5-16 ntawm cev xeeb tub, thiab ntawm qhov koob tshuaj txog li 96 μ g / kg tau muab rau cov luav hnub {{3 }} ntawm cev xeeb tub, tsis muaj kev cuam tshuam teratogenic pom. Raws li kev suav mg / m2, koob tshuaj rau nas yog sib npaug rau ob zaug qhov siab tshaj plaws tau pom zoo txhaj tshuaj rau tib neeg kev tswj hwm; Raws li cov tshuaj plasma AUC tus nqi, qhov kis tau tus kab mob hauv cov luav zoo ib yam li qhov kis tau tus mob ntawm qhov siab tshaj plaws pom zoo rau tib neeg cov tshuaj txhaj tshuaj. Ntawm qhov koob tshuaj ntawm 200 μ g / kg, fetal toxicity tau pom nyob rau hauv nas, manifested li nce poob tom qab implantation thiab txo tus naj npawb ntawm cov xeeb leej xeeb ntxwv. Qhov koob tshuaj tsis muaj txiaj ntsig yog 20 μ g / kg (xws li mg / m2, qis dua qhov siab tshaj plaws tau pom zoo rau tib neeg cov tshuaj txhaj).
Kev txhaj tshuaj subcutaneous ntawm dexmedetomidine rau hauv nas los ntawm hnub 16 ntawm cev xeeb tub mus rau lactation ua rau poob phaus hauv cov xeeb ntxwv ntawm koob tshuaj 8 thiab 32 μ g / kg (xws li mg / m2, qis dua qhov siab tshaj plaws tau pom zoo rau tib neeg cov tshuaj txhaj), thiab ncua kev ua haujlwm ntawm lub cev muaj zog tau pom nyob rau hauv pawg koob tshuaj 32 μ g / kg. F2 tiam ntawm 32 μ g / kg koob tshuaj pab pawg kuj pom embryonic thiab fetal toxicity. Tsis muaj toxicity tau pom ntawm koob tshuaj 2 μ g / kg.
Kev txhaj tshuaj subcutaneous ntawm radiolabeled dexmedetomidine hauv cov nas cev xeeb tub tau pom tias kev thauj khoom placental.
Cim npe nrov: Tuam Tshoj dexmedetomidine hydrochloride manufacturers, lwm tus neeg
